Risk of Recurrent Pregnancy Loss in the Ukrainian Population Using a Combined Effect of Genetic Variants: A Case-Control Study

We assessed the predictive ability of a combined genetic variant panel for risk recurrent pregnancy loss (RPL) through case-control study. Our study sample was from Ukraine and included 114 cases with idiopathic RPL 106 controls without any losses/complications at least one healthy child. genotyped variants within 12 loci reflecting main biological pathways involved in maintenance: blood coagulation (F2, F5, F7, GP1A), hormonal regulation (ESR1, ADRB2), endometrium placental function (ENOS, ACE), folate metabolism (MTHFR) inflammatory response (IL6, IL8, IL10). showed that score (GRS) calculated associated an increased (odds ratio 1.56, 95% CI: 1.21, 2.04, p = 8.7 × 10−4). The receiver operator characteristic (ROC) analysis resulted area under curve (AUC) 0.64 (95% 0.57, 0.72), indicating improved GRS to classify women RPL. Ιmplementation approach can help define higher complex multifactorial conditions such as Future well-powered genome-wide association studies will dissecting previously unknown further improve identification susceptibility.